The acridines

Agglutination of motile salmonellas by acridines.

Genetic studies of the determination of Salmonella flagella have suggested that the alternative antigenic phases correspond to two distinct homology groups, i.e., to factors at two distinct genetic loci, one for phase 1 ("specific phase"), and one for phase 2 ("group phase") (Lederberg and Edwards, 1953). It has, however, been generally understood that the two phases were equivalent to one anot...

Structures and cytotoxic properties of sponge-derived bisannulated acridines.

A reinvestigation of sponge natural products from additional Indo-Pacific collections of Xestospongiacf. carbonaria and X. cf. exigua has provided further insights on the structures, biological activities, and biosynthetic origin of bisannulated acridines. These alkaloids include one known pyridoacridine, neoamphimedine (2), and three new analogues, 5-methoxyneoamphimedine (4), neoamphimedine Y...

Spectrophotometric Determination and Computational Evaluation of the Rates of Hydrolysis of 9-Amino-Substituted Acridines

Aminoacridines have a long history in the drug and dye industries and display a wide range of biological and physical properties. Despite the historical relevance of 9-aminoacridines, there have been few studies investigating their stability. 9-Aminoacridines are known to hydrolyze at the C9-N15 bond, yielding acridones. In this study, the pH-dependent hydrolysis rates of a series of 9-substitu...

Prevention of the emergence of drug resistance in bacteria by acridines, phenothiazines, and dibenzocycloheptenes.

It has been found that, like Atabrine, the phenothiazine tranquilizers promazine, chlorpromazine, promethazine, levopromethazine, and Stelazine; the antidepressants (dibenz-azepine and dibenzocycloheptene derivatives) Tofranil, Pertofrane, cyclobenzaprine, Elavil, protriptyline, and 3-chlorodibenzocycloheptene; and the acridine derivatives acridine orange, acriflavin, SKF no. 16214-A2, SKF no. ...

The influence of acridines on the interaction of Staphylococcus aureus and staphylococcus K phage.